In Vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone

作者：Mila Jukić, Olivera Politeo, Milka Maksimović, Mia Milos, Mladen Miloš · 发表于：Phytotherapy Research · 年份：2006 · DOI：10.1002/ptr.2063 · 被引用次数：273 · 研究领域：Nigella sativa pharmacological applications、Cholinesterase and Neurodegenerative Diseases、Medicinal Plants and Neuroprotection

The aim of this study was to examine in vitro the inhibitory activity exerted by the main constituents of essential oil obtained from the aromatic plant Thymus vulgaris L. on acetylcholinesterase (AChE). The total essential oil and selected compounds, specifically linalool and thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone, were tested for AChE inhibition. Thymohydroquinone exhibited the strongest AChE inhibitory effect over the range of concentrations. The AChE inhibitory potential decreased in the following order: thymohydroquinone > carvacrol > thymoquinone > essential oil > thymol > linalool. It is interesting that the AChE inhibitory effect exerted by carvacrol was 10 times stronger than that exerted by its isomer thymol, although thymol and carvacrol have a very similar structure.