Further Studies on the Transmission of Staph. Aureus

作者：R. M. Hare, Mark Ridley · 发表于：BMJ · 年份：1958 · DOI：10.1136/bmj.1.5062.69 · 被引用次数：112 · 研究领域：Optical and Acousto-Optic Technologies、Geophysics and Sensor Technology、Visual perception and processing mechanisms

BACTERIAL ENDOCARDITIS BRmSH 69MEDICAL JOURNA of patients died from complications of endocarditis at about the time of completion of a six-weeks course of antibiotics adjudged to be curative, and, although no detailed study was made at necropsy concerning the viability of the bacterial colonies seen, their appearance gave no grounds for hope that, in these cases, several weeks less of treatment would have sufficed.In addition a case has already been quoted in which even six weeks was not long enough to effect cure.For penicillin-sensitive organisms fever that continues despite treatment may be due to systemic reaction to the antibiotic or to inadequate dosage.When considering this latter aspect it must be remembered that, while for streptococci of oral origin the bactericidal and bacteriostatic levels of penicillin are usually very similar, they are not always so, and this may explain failure of otherwise apparently adequate therapy (Berntsen, 1955).Cure of infection with so-called resistant organisms by the use of bacteriostatic drugs is not to be expected, and a drug or combination of drugs having bactericidal action must be sought (Garrod, 1953).The most generally useful combination at present is penicillin (10 to 20 mega units a day) with streptomycin 2 g. daily.But it is emphasized that treatment of such cases is part of a campaign planned in full co-operation with the bacteriologist, and rapid switching of drugs and dosage schedules merely serves to confuse the issue an...