Biocidal Activity of Polystyrenes That Are Cationic by Virtue of Protonation

作者：Michael A. Gelman, Bernard Weisblum, David M. Lynn, Samuel H. Gellman · 发表于：Organic Letters · 年份：2004 · DOI：10.1021/ol036341+ · 被引用次数：165 · 研究领域：Antimicrobial Peptides and Activities、Antimicrobial agents and applications、Polydiacetylene-based materials and applications

[structure: see text] Poly(1) kills bacteria (Gram-positive and -negative) and lyses human erythrocytes; this biocidal profile is similar to that of the peptide toxin mellitin. Poly(1) has antibacterial activity comparable to that of a potent derivative of the host defense peptide magainin II, but lacks magainin's selectivity for bacteria over erythrocytes. An analogous N-quaternized polymer, poly(3), is less biocidal than poly(1), suggesting that reversible N-protonation leads to greater biocidal activity than does irreversible N-quaternization.