cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

作者：John E. Sims, Caril J. March, David J. Cosman, Michael B. Widmer, H. Robson MacDonald, Catherine J. McMahan, Catherine E. Grubin, Janis M. Wignall, Jana L. Jackson, Susan M. Call, Della J. Friend, A Alpert, Steven A. Gillis, David L. Urdal, Steven Dower · 发表于：Science · 年份：1988 · DOI：10.1126/science.2969618 · 被引用次数：896 · 研究领域：Immune Response and Inflammation、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.