Recognition of Two Distinct Groups of Human IgM and IgA Based on Different Binding to Staphylococci

作者：Morten Harboe, Ivar Følling · 发表于：Scandinavian Journal of Immunology · 年份：1974 · DOI：10.1111/j.1365-3083.1974.tb01280.x · 被引用次数：150 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Glycosylation and Glycoproteins Research、T-cell and B-cell Immunology

Labeled monoclonal IgM was bound to the Cowan I strain of Staphylococcus aureus in the absence of anti‐IgM antibody This binding was inhibited by 11 of 33 monoclonal IgM proteins; 22 failed to inhibit Agammaglobulinemic serum alto failed to inhibit High concentrations of IgG inhibited the binding of IgM Se to staphylococci, but IgG and IgM probably react with different receptors on tin bacterial surface. Polyclonal IgM from all of 17 individuals tested inhibited the binding of IgM Se to staphylococci, which indicates that the distinction corresponds to an IgM subclass rather than to an allotype. Two of seven monoclonal IgA proteins also inhibited the binding of IgM Se to staphylococci.