Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

作者：Diego J. Walther, Jens‐Uwe Peter, Saleh Bashammakh, Heide Hörtnagl, Mechthild Voits, Heidrun Fink, Michael Bäder · 发表于：Science · 年份：2003 · DOI：10.1126/science.1078197 · 被引用次数：1578 · 研究领域：Neurotransmitter Receptor Influence on Behavior、Psychedelics and Drug Studies、Tryptophan and brain disorders

The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] is causally involved in multiple central nervous facets of mood control and in regulating sleep, anxiety, alcoholism, drug abuse, food intake, and sexual behavior ([1][1]). In peripheral tissues, 5-HT regulates vascular tone, gut motility,