Stress-Induced Suppression of Immunity in Adrenalectomized Rats

作者：Steven E. Keller, Jay Michael Weiss, Steven J. Schleifer, Neil E. Miller, Marvin Stein · 发表于：Science · 年份：1983 · DOI：10.1126/science.6612346 · 被引用次数：390 · 研究领域：Stress Responses and Cortisol、Exercise and Physiological Responses、Immune Response and Inflammation

Stress-induced suppression of lymphocyte stimulation by phytohemagglutinin was demonstrated in Isolated lymphocytes and in cultures of whole blood from adrenalectomized rats. The results demonstrate that corticosteroid independent mechanisms participate in the suppression of lymphocyte function by stressors. Stress-induced lymphopenia, however, was found to be adrenal dependent, indicating that the modulation of immunity by stress is complex and multidetermined.