Glucosamine Hydrochloride Functionalized Water‐Soluble Conjugated Polyfluorene: Synthesis, Characterization, and Interactions with DNA

作者：Qi Chen, Qianyi Cheng, Yanchao Zhao, Bao‐Hang Han · 发表于：Macromolecular Rapid Communications · 年份：2009 · DOI：10.1002/marc.200900226 · 被引用次数：26 · 研究领域：Advanced biosensing and bioanalysis techniques、Click Chemistry and Applications、Luminescence and Fluorescent Materials

Novel glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene was easily synthesized through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. The water-solubility and biocompatibility of the polymer were improved after grafting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single-stranded DNA was studied by spectrofluorometric titration.