Ranking of excitatory amino acids by the antagonists glutamic acid diethylester and D -α-aminoadipic acid

作者：T.P. Hicks, Judith G. Hall, H. McLennan · 发表于：Canadian Journal of Physiology and Pharmacology · 年份：1978 · DOI：10.1139/y78-143 · 被引用次数：78 · 研究领域：Amino Acid Enzymes and Metabolism、Neuroscience and Neuropharmacology Research、Receptor Mechanisms and Signaling

A separation of the excitatory actions of the amino acids upon thalamic neurones of rats anaesthetized with urethane has been accomplished through the use of two antagonists. It has been possible to rank the excitatory compounds in their order of susceptibility to D-alpha-aminoadipic acid (DalphaAA) and L-glutamic acid diethylester (GDEE). The observation that the ranking orders of the excitants differ for these two antagonists permits an analysis of the types of receptors with which the amino acid excitants react. The results support the proposition that more than one neuronal receptor sensitive to the amino acids exists.