RNA: Guiding Gene Silencing

作者：Marjori A Matzke, Antonius J. M. Matzke, Jan M. Kooter · 发表于：Science · 年份：2001 · DOI：10.1126/science.1063051 · 被引用次数：375 · 研究领域：Plant Molecular Biology Research、Chromosomal and Genetic Variations、Plant Virus Research Studies

In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences. RNA silencing is a potent means to counteract foreign sequences and could play an important role in plant and animal development.