An Exact Test for Hardy-Weinberg and Multiple Alleles

作者：Edward J. Louis, Everett R. Dempster · 发表于：Biometrics · 年份：1987 · DOI：10.2307/2531534 · 被引用次数：334 · 研究领域：Evolution and Genetic Dynamics

Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution and is equivalent to Levene's conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.