Temporal Coordination of Physiologic Function

作者：Franz Halberg · 发表于：Cold Spring Harbor Symposia on Quantitative Biology · 年份：1960 · DOI：10.1101/sqb.1960.025.01.031 · 被引用次数：299 · 研究领域：Dietary Effects on Health、Diet and metabolism studies、Circadian rhythm and melatonin

The organism, as well as its parts, usually does not function at a constant rate along a 24-hour scale; many of its diverse, discrete changes do not recur at purely chance intervals. More often than might be expected from classical physiologic knowledge, we encounter circadian (circa, dies; [1–3]) repetitive sequences of events; this organization in time has apparently evolved through genetic adaptation of body metabolism to a terrestrial environment (for references see [1]).