Experimental Disseminated Candidiasis. II, Administration of Glucocorticosteroids, Susceptibitity to Infection, and Immunity

作者：Douglas L. Hurley, James E. Balow, Anthony S. Fauci · 发表于：The Journal of Infectious Diseases · 年份：1975 · DOI：10.1093/infdis/132.4.393 · 被引用次数：38 · 研究领域：Antifungal resistance and susceptibility、Immune Response and Inflammation、T-cell and B-cell Immunology

A model of experimental disseminated candidiasis in inbred guinea pigs was used for study of the effects of both short-acting and long-acting glucocorticosteroid administration on the susceptibility to infection, the development of in vivo and in vitro parameters of cell-mediated immunity, and the expression of already established Candida-specific, cell-mediated immunity. Results revealed that long-acting glucocorticosteroids markedly potentiated infection, increasing mortality and suppressing already established cellular immune parameters. The development of cellular immunity to Candida was not impaired. Short-acting glucocorticosteroids, however, did not potentiate infection, and they affected neither the development nor the expression of immune parameters.