A Mixture of High Molecular Alkyl-dimethyl-benzyl-ammonium Chlorides as an Antiseptic.

作者：Cecil G. Dunn, A. E. Meyer · 发表于：Experimental Biology and Medicine · 年份：1936 · DOI：10.3181/00379727-35-9005p · 被引用次数：13 · 研究领域：Coconut Research and Applications、Essential Oils and Antimicrobial Activity、Advanced Chemical Sensor Technologies

possess characteristics highly desirable in an antiseptic or germicide. The product is obtained as a mixture of homologues in which the alkyls represent radicals derived from the fatty acids of coconut oil. The mixture has been found to be quite uniform in composition. This compound is an amber-colored solid of soap-like consistency. From the solid is generally prepared a 10% aqueous stock solution, which is slightly acid in reaction and which has a surface tension of less than 36 dynes/cm. Germicidal tests were carried out according to F.D.A. methods. The cultures of Staphylococcus aureus and Eberthella typhosa used were secured from the Food and Drug Administration at Washington, D. C., the streptococci from the Boston City Hospital, and the other organisms from the collection of the Department of Biology and Public Health at the Massachusetts Institute of Technology. All the bacteria were cultivated in Reddish broth, with the exception of the Streptococci, which were grown in Bacto-brain-heart infusion containing 0.1% agar. The molds were grown on Sabouraud's dextrose-agar and subcultured in Sabouraud's dextrose-broth. Both Gram-positive and Gram-negative pathogenic organisms were readily destroyed by the ammonium compound in high dilution. The hemolytic streptococcus, E. typhosa and C. hominis were destroyed in the highest dilution at 37°C. Monilia albicans was most resistant at 20°C., but was quickly destroyed by a 1/10,000 dilution. Effect of Temperature. The germicidal...