Parallel simulation of patient‐specific atherosclerotic arteries for the enhancement of intravascular ultrasound diagnostics

作者：Daniel Balzani, D. Böse, Dominik Brands, Raimund Erbel, Axel Klawonn, Oliver Rheinbach, Jörg Schröder · 发表于：Engineering Computations · 年份：2012 · DOI：10.1108/02644401211271645 · 被引用次数：40 · 研究领域：Elasticity and Material Modeling、Coronary Interventions and Diagnostics、Cardiovascular Health and Disease Prevention

Purpose The purpose of this paper is to present a computational framework for the simulation of patient‐specific atherosclerotic arterial walls. Such simulations provide information regarding the mechanical stress distribution inside the arterial wall and may therefore enable improved medical indications for or against medical treatment. In detail, the paper aims to provide a framework which takes into account patient‐specific geometric models obtained by in vivo measurements, as well as a fast solution strategy, giving realistic numerical results obtained in reasonable time. Design/methodology/approach A method is proposed for the construction of three‐dimensional geometrical models of atherosclerotic arteries based on intravascular ultrasound virtual histology data combined with angiographic X‐ray images, which are obtained on a routine basis in the diagnostics and medical treatment of cardiovascular diseases. These models serve as a basis for finite element simulations where a large number of unknowns need to be calculated in reasonable time. Therefore, the finite element tearing and interconnecting‐dual primal (FETI‐DP) domain decomposition method is applied, to achieve an efficient parallel solution strategy. Findings It is shown that three‐dimensional models of patient‐specific atherosclerotic arteries can be constructed from intravascular ultrasound virtual histology data. Furthermore, the application of the FETI‐DP domain decomposition method leads to a fast numerical...