Initiation of meiotic recombination is independent of interhomologue interactions.

作者：Larry A. Gilbertson, Franklin W. Stahl · 发表于：Proceedings of the National Academy of Sciences · 年份：1994 · DOI：10.1073/pnas.91.25.11934 · 被引用次数：44 · 研究领域：DNA Repair Mechanisms、Fungal and yeast genetics research、Bacterial Genetics and Biotechnology

In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports models that view double-strand breaks as initiating events and crossing-over as a consequence of repair of these breaks.