Rifampicin and vitamin D metabolism

作者：Martin J Brodie, Alan R. Boobis, Colin T. Dollery, C. J. Hillyard, D J Brown, I. Maclntyre, B K Park · 发表于：Clinical Pharmacology & Therapeutics · 年份：1980 · DOI：10.1038/clpt.1980.115 · 被引用次数：105 · 研究领域：Pharmacological Effects and Toxicity Studies、Vitamin D Research Studies、Parathyroid Disorders and Treatments

A 2-wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent fall in plasma 25-hydroxycholecalciferol (25-OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6 beta-hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25-dihydroxycholecalciferol, parathyroid hormone, and calcitonin were not altered. The fall in 25-OHD may represent the earliest lesion of drug-induced osteomalacia.