Eat Dirt — The Hygiene Hypothesis and Allergic Diseases

作者：Scott T. Weiss · 发表于：New England Journal of Medicine · 年份：2002 · DOI：10.1056/nejme020092 · 被引用次数：183 · 研究领域：Asthma and respiratory diseases、Dermatology and Skin Diseases、Eosinophilic Esophagitis

There has been an epidemic of both autoimmune diseases (in which the immune response is dominated by type 1 helper T [Th1] cells, such as type 1 diabetes, Crohn's disease, and multiple sclerosis) and allergic diseases (in which the immune response is dominated by type 2 helper T [Th2] cells, such as asthma, allergic rhinitis, and atopic dermatitis), as documented in the article by Bach in this issue of the Journal. 1 The occurrence of these diseases is higher in more affluent, Western, industrialized countries. One theory proposed to explain this increase in the prevalence of autoimmune and allergic diseases is . . .