Faithful Expression of Imprinted Genes in Cloned Mice

作者：Kimiko Inoue, Takashi Kohda, Jiyoung Lee, Narumi Ogonuki, Keiji Mochida, Yoko Noguchi, Kentaro Tanemura, Tomoko Kaneko‐Ishino, Fumitoshi Ishino, Atsuo Ogura · 发表于：Science · 年份：2002 · DOI：10.1126/science.295.5553.297 · 被引用次数：271 · 研究领域：Genetic Syndromes and Imprinting、Epigenetics and DNA Methylation、Pluripotent Stem Cells Research

Phenotypic anomalies have been observed among animals cloned from somatic cells, putatively caused by epigenetic alterations, especially those of imprinted genes ([1][1]). However, the complexity of potentially contributory technical factors associated with nuclear transfer (NT) experiments could