Stability of Asymmetric Phospholipid Membranes

作者：Demetrios Papahadjopoulos, Shinpei Ohki · 发表于：Science · 年份：1969 · DOI：10.1126/science.164.3883.1075 · 被引用次数：101 · 研究领域：Lipid Membrane Structure and Behavior、Electrochemical sensors and biosensors、Electrochemical Analysis and Applications

Bilayers (black films) composed of phosphatidylserine are unstable under conditions of asymmetric distribution of calcium or hydrogen ions with respect to the membrane. Addition of calcium ions to the solution (100 millimolar sodium chloride, pH 7.0) on one side only, produces lowering of the direct-current resistance and results in breaking of the membrane. However, with calcium ions on both sides the membranes are stable and show very high electrical resistance.