The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

作者：Masakazu Hattori, John B. Buse, R. A. JACKSON, Laurie H. Glimcher, Martin E. Dorf, Manabu Minami, S. Makino, Kenta Moriwaki, Hideshi Kuzuya, H Imura, William M. Strauss, Jon G. Seidman, George S. Eisenbarth · 发表于：Science · 年份：1986 · DOI：10.1126/science.3003909 · 被引用次数：422 · 研究领域：T-cell and B-cell Immunology、Diabetes and associated disorders、Immune Cell Function and Interaction

Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.