The Human Hematopoietic Colony-Stimulating Factors

作者：Steven C. Clark, Robert Kamen · 发表于：Science · 年份：1987 · DOI：10.1126/science.3296190 · 被引用次数：1687 · 研究领域：Acute Myeloid Leukemia Research、Erythrocyte Function and Pathophysiology、Hematopoietic Stem Cell Transplantation

The complementary DNAs and genes encoding the four major human myeloid growth factors--granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3--have all been molecularly cloned. These DNA clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for the large-scale production of the recombinant growth factor proteins. These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.