A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

作者：Bruno Lemaître, Elisabeth KROMER‐METZGER, Lydia Michaut, Émmanuelle Nicolas, Marie Meister, Philippe Georgel, Jean‐Marc Reichhart, Jules A. Hoffmann · 发表于：Proceedings of the National Academy of Sciences · 年份：1995 · DOI：10.1073/pnas.92.21.9465 · 被引用次数：643 · 研究领域：Antimicrobial Peptides and Activities、Invertebrate Immune Response Mechanisms、Insect symbiosis and bacterial influences

In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background. These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin.