CuI/PPh 3 ‐catalyzed Sonogashira coupling reaction of aryl iodides with terminal alkynes in water in the absence of palladium

作者：Jin Tao Guan, Guang‐Ao Yu, Lei Chen, Tan Qing Weng, Jing Yuan, Sheng Hua Liu · 发表于：Applied Organometallic Chemistry · 年份：2008 · DOI：10.1002/aoc.1474 · 被引用次数：54 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions

Abstract The Sonogashira cross‐coupling of aryl iodides with terminal alkynes catalyzed by a simple and inexpensive catalyst system of CuI/PPh 3 in water as the sole solvent has been reported. In the presence of CuI/PPh 3 , with KOH used as a base, a number of aryl iodides were treated with alkynes to afford the corresponding products in moderate to excellent yields. Copyright © 2008 John Wiley & Sons, Ltd.