Fluoride absorption from swallowed fluoride toothpaste

作者：B Forsman, Yngve Ericsson · 发表于：Community Dentistry And Oral Epidemiology · 年份：1973 · DOI：10.1111/j.1600-0528.1973.tb01327.x · 被引用次数：25 · 研究领域：Fluoride Effects and Removal、Bone and Dental Protein Studies、Folate and B Vitamins Research

ABSTRACT Absorption of fluoride (F) from ingested toothpastes was studied in rats, in adult humans and to some extent in children. The parameters analyzed were mainly 4‐hour unabsorbed F in the rats and 9‐hour urinary excretion in the humans. Five commercial and four experimental preparations were tested. The results indicate that the polishing agents calcium phosphate and calcium carbonate prevent a considerable fraction of the F content from being absorbed, whether this is present as F‐ or PO3F– ions. Polishing agents that are inert towards F do not appear to inhibit the F absorption, but the high bicarbonate content of one toothpaste may exert some inhibition by its osmosis.