LETHALLY IRRADIATED DOGS GIVEN INFUSIONS OF FETAL AND ADULT HEMATOPOIETIC TISSUE

作者：E. Donnall Thomas, John A. Collins, S Kasakura, Joseph W. Ferrebee · 发表于：Transplantation · 年份：1963 · DOI：10.1097/00007890-196301040-00010 · 被引用次数：12 · 研究领域：Mesenchymal stem cell research、Xenotransplantation and immune response、Congenital heart defects research

Lethally irradiated dogs, 1500 r, were given infusions of fetal hematopoietic tissue (16 dogs), adult marrow and fetal hematopoietic tissue (17 dogs), and adult marrow and adult spleen (8 dogs). The incidence of successful engraftment, graft rejection, and secondary syndromes was found to be similar to that observed after adult marrow alone. It is concluded that in this species as in the mouse successful marrow engraftment and survival of secondary syndromes depend primarily on a choice of donor and recipient of reasonable histocompatibility.