PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?

作者：Béatrice Desvergne, Walter Wahli · 发表于：Birkhäuser Boston eBooks · 年份：1995 · DOI：10.1007/978-1-4684-6840-3_5 · 被引用次数：51 · 研究领域：Peroxisome Proliferator-Activated Receptors、Nuclear Receptors and Signaling、Retinoids in leukemia and cellular processes

Retinoids as well as steroid and thyroid hormones are small lipophilic molecules that exert an intricate array of combinatorial effects during embryogenesis, cellular differentiation, and homeostasis in the adult organism. Complexity in the signalling pathway of these hormones results from the functional association of low affinity cytoplasmic hormone binding proteins and high affinity nuclear hormone receptors. The latter interact with polymorphic response elements linked to target genes and mediate the hormonal response at the transcriptional level. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.