Identification of Hodgkin and sternberg‐reed cells as a unique cell type derived from a newly‐detected small‐cell population

作者：Harald Stein, Johannes Gerdes, Ulrich Schwab, Hilmar Lemke, David Y. Mason, Andreas Ziegler, Wolfgang Schienle, Volker Diehl · 发表于：International Journal of Cancer · 年份：1982 · DOI：10.1002/ijc.2910300411 · 被引用次数：422 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Lymphoma Diagnosis and Treatment、Immunotherapy and Immune Responses

In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin of H and SR cells and, secondly, to determine whether there is any evidence to support recent suggestions that H and SR cells differ antigenically between different histological categories of Hodgkin's disease. Frozen sections (from 24 cases) and paraffin sections (83 cases) were stained by immunoenzymatic methods and the results compared with those obtained from staining a wide variety of reactive and neoplastic tissue samples (including examples of tuberculosis, sarcoidosis, malignant histiocytosis, histiocytosis X, osteomyelosclerosis and non-Hodgkin's lymphoma). The results revealed that H and SR cells of all types of Hodgkin's disease consistently lack markers found on null cells, B cells, T cells, cells of monocyte/macrophage series, interdigitating reticulum cells, dendritic reticulum cells and erythropoietic and thrombopoietic cells. However, H and SR cells constantly expressed an antigen detectable with the recently produced monoclonal antibody Ki-I. The vast majority of typical and lacunar type H and SR cells contained the granulocyte-related antigens detected by monoclonal antibodies TU5, TU6, TU9 and 3C4, whereas other more or less specific granulopoie...