Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

作者：Timothy F. Osborne · 发表于：Journal of Biological Chemistry · 年份：2000 · DOI：10.1074/jbc.r000017200 · 被引用次数：521 · 研究领域：Cholesterol and Lipid Metabolism、Peroxisome Proliferator-Activated Receptors、Drug Transport and Resistance Mechanisms

sterol regulatory element-binding protein sterol regulatory element sterol regulatory element-binding protein-1c or adipocyte differentiation and determination factor-1 basic helix-loop-helix bHLH leucine zipper low density lipoprotein cAMP-response element-binding protein vitamin D receptor-interacting protein activator-recruited cofactor fatty acid synthase polyunsaturated fatty acid(s) The sterol regulatory element-binding proteins (SREBPs)1 were first identified by two groups working independently on cholesterol metabolism (1Yokoyama C. Wang X. Briggs M.R. Admon A. Wu J. Hua X. Goldstein J.L. Brown M.S. Cell. 1993; 75: 185-197Crossref Google Scholar, 2Hua X. Yokoyama C. Wu J. Briggs M.R. Brown M.S. Goldstein J.L. Wang X. Proc. Natl. Acad. Sci. U. S. A. 1993; 90: 11603-11607Crossref PubMed Scopus (522) Google Scholar) and fat cell differentiation (3Tontonoz P. Kim J.B. Graves R.A. Spiegelman B.M. Mol. Cell. Biol. 1993; 13: 4753-4759Crossref PubMed Scopus (545) Google Scholar). Subsequent studies have demonstrated there are three major SREBP isoforms encoded by two different genes (4Brown M.S. Goldstein J.L. Cell. 1997; 89: 331-340Abstract Full Text Full Text PDF PubMed Scopus (3097) Google Scholar). These unique members of the basic helix-loop-helix leucine zipper (bHLHLZ) family of transcriptional regulatory proteins can be distinguished from other family members by two characteristics. The first is they are synthesized as precursors that are threaded into membranes of th...