Hyaline Vascular Castleman's Disease With HMGIC Rearrangement in Follicular Dendritic Cells

作者：Kristof Cokelaere, Maria Dêbiec‐Rychter, C. De Wolf‐Peeters, A Hagemeijer, Raf Sciot · 发表于：The American Journal of Surgical Pathology · 年份：2002 · DOI：10.1097/00000478-200205000-00013 · 被引用次数：88 · 研究领域：Viral-associated cancers and disorders、Histiocytic Disorders and Treatments、Lymphoma Diagnosis and Treatment

Chromosomal aberrations involving chromosome segment 12q13-15 are a common finding in a variety of benign mesenchymal tumors. The target gene encodes for HMGIC, a member of the high mobility group protein family. These proteins act as architectural transcription factors. HMGIC plays a role as a common genetic denominator in benign mesenchymal tumorigenesis. We report a case of hyaline vascular Castleman's disease with intragenic HMGIC rearrangement, due to a clonal cytogenetic aberration involving the long arm of chromosome 12 [46,XX, add(1)(q21),der(6)t(6;12) (q23;q15),add(7)(p22), -9,inv(9)(p11q13),del(12)(q15),+mar] obtained after short-term primary cultures. A combined immunocytologic-cytogenetic approach enabled us to demonstrate the exclusive presence of HMGIC rearrangement in anti-CD21 reactive follicular dendric cells. This finding confirms that a clonal proliferation of follicular dendritic cells occurs in the hyaline vascular variant of Castleman's disease. It also provides a possible molecular pathway explaining stromal overgrowths and stromal neoplasms developing from this disorder.