Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

作者：Michael Berelowitz, Márta Szabó, Lawrence A. Frohman, Susan L. Firestone, Lily Chu, Raymond Lauren Hintz · 发表于：Science · 年份：1981 · DOI：10.1126/science.6262917 · 被引用次数：833 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Regulation of Appetite and Obesity、Hypothalamic control of reproductive hormones

Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.