The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

作者：Gunbjørg Svineng, Chandra Sekhar Ravuri, Oddveig Rikardsen, Nils‐Erik Huseby, Jan‐Olof Winberg · 发表于：Connective Tissue Research · 年份：2008 · DOI：10.1080/03008200802143166 · 被引用次数：121 · 研究领域：Protease and Inhibitor Mechanisms、Cell Adhesion Molecules Research、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Cell adhesion and migration is largely dependent on integrin binding to extracellular matrix, and several signalling pathways involved in these processes have been shown to be modified by reactive oxygen species (ROS). In fact, integrin activation is linked to increased ROS production by NADPH-oxidases, 5-lipoxygenase, and release from mitochondria. Cell migration is intimately linked to degradation of the extracellular matrix, and activated matrix metalloproteinases (MMPs) are a prerequisite for cancer cell invasion and metastasis. In this minireview, we focus on the interplay between integrin-mediated ROS production and MMP expression as well as its biological and pathobiological significance.