Genetic Variations and Transplant Outcomes

作者：Bernd Krüger, Bernd Schröppel · 发表于：Nephron Clinical Practice · 年份：2010 · DOI：10.1159/000320904 · 被引用次数：10 · 研究领域：Complement system in diseases、Platelet Disorders and Treatments、Immune Cell Function and Interaction

Extensive genetic variation has been described in molecules regulating innate and adaptive immunity, pharmacokinetics, coagulation, and fibrosis. However, large prospective studies need to be performed to define the clinical consequences of such variation and the potential benefits of genotyping these markers for patients. The purpose of this review is to summarize recent data describing associations of polymorphisms in both immunological and non-immunological molecules with transplant outcomes, and discuss their clinical implications and limitations.