Alcohol as a Risk Factor for Type 2 Diabetes

作者：Dolly O. Baliunas, Benjamin J. Taylor, Hyacinth M. Irving, Michael Roerecke, Jayadeep Patra, Satya Sundar Gajendra Mohapatra, Jürgen Rehm · 发表于：Diabetes Care · 年份：2009 · DOI：10.2337/dc09-0227 · 被引用次数：704 · 研究领域：Alcohol Consumption and Health Effects、Substance Abuse Treatment and Outcomes、Diabetes, Cardiovascular Risks, and Lipoproteins

OBJECTIVE: To clarify the dose-response relationship between alcohol consumption and type 2 diabetes. RESEARCH DESIGN AND METHODS: A systematic computer-assisted and hand search was conducted to identify relevant articles with longitudinal design and quantitative measurement of alcohol consumption. Adjustment was made for the sick-quitter effect. We used fractional polynomials in a meta-regression to determine the dose-response relationships by sex and end point using lifetime abstainers as the reference group. RESULTS: The search revealed 20 cohort studies that met our inclusion criteria. A U-shaped relationship was found for both sexes. Compared with lifetime abstainers, the relative risk (RR) for type 2 diabetes among men was most protective when consuming 22 g/day alcohol (RR 0.87 [95% CI 0.76-1.00]) and became deleterious at just over 60 g/day alcohol (1.01 [0.71-1.44]). Among women, consumption of 24 g/day alcohol was most protective (0.60 [0.52-0.69]) and became deleterious at about 50 g/day alcohol (1.02 [0.83-1.26]). CONCLUSIONS: Our analysis confirms previous research findings that moderate alcohol consumption is protective for type 2 diabetes in men and women.