From the Decidual Cell Internet: Trophoblast-Recognizing T Cells

作者：Petra Arck, J. Dietl, David A. Clark · 发表于：Biology of Reproduction · 年份：1999 · DOI：10.1095/biolreprod60.2.227 · 被引用次数：51 · 研究领域：Reproductive System and Pregnancy、Pregnancy and preeclampsia studies、Immune Cell Function and Interaction

The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal gammadelta T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.