Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy Scale

作者：Guido Cavaletti, G. Bogliun, L. Marzorati, A. Zincone, Marco Piatti, N. Colombo, Gabriella Parma, Andrea Alberto Lissoni, F. Fei, Sante Cundari, Claudio Zanna · 发表于：Neurology · 年份：2003 · DOI：10.1212/01.wnl.0000092015.03923.19 · 被引用次数：185 · 研究领域：Cancer Treatment and Pharmacology、Chemotherapy-related skin toxicity、Glioma Diagnosis and Treatment

The authors compared clinically based neurotoxicity scales with the Total Neuropathy Scale, with the aim of improving the grading of the severity of chemotherapy-induced peripheral neuropathy (CIPN). The severity of CIPN was evaluated in a series of 60 women treated with cisplatin- and paclitaxel-based chemotherapy. A reduced version of TNS (TNSr) was also compared. The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity.