Serum Bilirubin Level is Negatively Correlated With Disease Progression of Peripheral Arterial Disease

作者：Haiyang Wang, Peng Han, Weihui Zhang, Bing Liu, Hali Li, Haijun Wang, Renping Huang · 发表于：Angiology · 年份：2011 · DOI：10.1177/0003319711425175 · 被引用次数：15 · 研究领域：Heme Oxygenase-1 and Carbon Monoxide、Neonatal Health and Biochemistry、Methemoglobinemia and Tumor Lysis Syndrome

We determined whether low bilirubin level is a risk factor for peripheral arterial disease (PAD). We recruited 318 patients with PAD and 100 healthy volunteers. Patients were divided into 4 groups by the Fontaine classification for PAD, namely, group 1 (grade 1, n = 4); group 2 (grade 2, n = 114), group 3 (grade 3, n = 164), and group 4 (grade 4, n = 36). Total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL) levels were compared using stepwise multiple regressions adjusted for selected factors. After adjusting for gender, age, smoking, and diastolic blood pressure, serum levels of T-BIL, D-BIL, and I-BIL were significantly lower in the PAD group (P < .05). Patients with grade 4 PAD showed significantly (P < .05) lower levels of T-BIL when compared with grade 2 patients. We concluded that serum bilirubin levels are negatively correlated with the severity and progression of PAD.