DNA Sequence of Two Closely Linked Human Leukocyte Interferon Genes

作者：Richard M. Lawn, John P. Adelman, Thomas J. Dull, Mitchell S. Gross, David V. Goeddel, Axel Ullrich · 发表于：Science · 年份：1981 · DOI：10.1126/science.6165082 · 被引用次数：108 · 研究领域：Bacteriophages and microbial interactions、interferon and immune responses、RNA and protein synthesis mechanisms

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or alpha type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.