Genetic and Environmental Contributions to the Co-occurrence of Depressive Personality Disorder and DSM-IV Personality Disorders

作者：Ragnhild Ørstavik, Kenneth S. Kendler, Espen Røysamb, Nikolai Olavi Czajkowski, Kristian Tambs, Ted Reichborn‐Kjennerud · 发表于：Journal of Personality Disorders · 年份：2012 · DOI：10.1521/pedi.2012.26.3.435 · 被引用次数：7 · 研究领域：Personality Disorders and Psychopathology、Mental Health and Psychiatry、Psychotherapy Techniques and Applications

One of the main controversies with regard to depressive personality disorder (DPD) concerns the co-occurrence with the established DSM-IV personality disorders (PDs). The main aim of this study was to examine to what extent DPD and the DSM-IV PDs share genetic and environmental risk factors, using multivariate twin modeling. The DSM-IV Structured Interview for Personality was applied to 2,794 young adult twins. Paranoid PD from Cluster A, borderline PD from Cluster B, and all three PDs from Cluster C were independently and significantly associated with DPD in multiple regression analysis. The genetic correlations between DPD and the other PDs were strong (.53-.83), while the environmental correlations were moderate (.36-.40). Close to 50% of the total variance in DPD was disorder specific. However, only 5% was due to disorder-specific genetic factors, indicating that a substantial part of the genetic vulnerability to DPD also increases the vulnerability to other PDs.