Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicola

作者：R. A. Bucknall, H. Moores, Rebecca Simms, Barrie Hesp · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1973 · DOI：10.1128/aac.4.3.294 · 被引用次数：142 · 研究领域：Mycobacterium research and diagnosis、Cytomegalovirus and herpesvirus research、Parasitic Infections and Diagnostics

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.