The Effect of Supplementary Oral Nutrition in Poorly Nourished Patients with Chronic Obstructive Pulmonary Disease

作者：John Efthimiou, J Fleming, C. Gomes, SG Spiro · 发表于：American Review of Respiratory Disease · 年份：1988 · DOI：10.1164/ajrccm/137.5.1075 · 被引用次数：311 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Dysphagia Assessment and Management、Nutrition and Health in Aging

Abstract We carried out a prospective, randomized, controlled trial to investigate the effect of a 3-month period of supplementary oral nutrition in 14 poorly nourished outpatients with COPD. Seven patients were randomized into Group 1 who received their normal diet during Months 1 to 3, a supplemented diet during Months 4 to 6, and their original normal diet during Months 7 to 9. The other 7 patients received their normal diet for the entire 9-month study period (Group 2). Seven well-nourished patients (Group 3) matched for age and severity of air-flow obstruction served as control subjects; they received their normal diet for the 9-month study period. Measurements of nutritional status, respiratory muscle and handgrip strength, sternomastoid muscle function (including frequency/force curves, maximal relaxation rate, and a fatigability test), lung function, arterial blood gas tensions, general well-being and breathlessness scores, and 6-min walking distances were carried out monthly in all patients. At the start of the study, the poorly nourished patients had lower mean daily calorie and protein intakes than did the well-nourished patients. The poorly nourished patients had lower respiratory muscle and handgrip strength, and abnormal contractility and increased fatigability of the sternomastoid muscle compared with those in the well-nourished patients. After 3 months of supplementary oral nutrition, there was a significant improvement in the nutritional status of Group 1 pat...