Tritiated Digoxin

作者：James E. Doherty, William J. Flanigan, Marvin L. Murphy, Robert T. Bulloch, G. L. DALRYMPLE, Owen W. Beard, William Harvey Perkins, Jacquelyn Gammill, Joyce Sherwood · 发表于：Circulation · 年份：1970 · DOI：10.1161/01.cir.42.5.867 · 被引用次数：112 · 研究领域：Pediatric Hepatobiliary Diseases and Treatments、Biliary and Gastrointestinal Fistulas、Gallbladder and Bile Duct Disorders

Metabolic turnover studies performed on six patients with surgically induced biliary fistula given tritiated digoxin reveal virtually all stool excretion of digoxin to be derived from bile. This establishes the relative lack of recycling of digoxin as an important factor in digoxin metabolism. This is probably related to its polar chemical structure and is a determinant of its clinical duration of action in human subjects. The amount of digoxin in the enterohepatic circulation (recycling) was calculated to be 6.5% of the administered dose and absolute absorption to be 85% in human subjects.