Superoxide Anion Radical (O·2), Superoxide Dismutases, and Related Matters

作者：Irwin Fridovich · 发表于：Journal of Biological Chemistry · 年份：1997 · DOI：10.1074/jbc.272.30.18515 · 被引用次数：1349 · 研究领域：Redox biology and oxidative stress、Glutathione Transferases and Polymorphisms、Cholinesterase and Neurodegenerative Diseases

A field of inquiry may be said to have come of age when conclusions initially viewed as remarkable or even unbelievable are accepted as commonplace. Study of the biology of the superoxide anion radical and of related free radicals, and the defenses thereto, has now reached this happy state of maturity. Superoxide and even hydroxyl radicals are now known to be produced in living systems, and elaborate systems of defense and repair, which minimize the ravages of these reactive species, have been described. New members of the superoxide dismutase, catalase, and peroxidase families of defensive enzymes are being found, as are new targets that are modified by O·̄2. In addition, the involvement of O·̄2 in both physiological and pathological processes is being established. A weighty tome would be needed to encompass a comprehensive coverage of this field of study. This review will describe only aspects of the biology of oxygen radicals that currently engage the interest of the writer. Hopefully they will also be of interest to the reader. Other recent reviews may serve to fill the gaps in this one (1Miller A.F. Sorkin D.L. Comments Mol. Cell. Biophys. 1997; 9: 1-48Google Scholar, 2Gardner, P. R. (1997) BioSci. Rep., in press.Google Scholar, 3McCord J.M. Proc. Soc. Exp. Biol. Med. 1995; 209: 112-117Crossref PubMed Scopus (136) Google Scholar, 4Valentine J.S. Ellerby L.M. Graden J.A. Nichida C.R. Gralla E.B. Kessissoglou D.P. Bioinorganic Chemistry. Kluwer Academic Publishers Group, D...