Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease

作者：Marta Marchetti, Beatrice Aricò, Daniela Burroni, Natale Figura, Rino Rappuoli, PAOLO GHIARA · 发表于：Science · 年份：1995 · DOI：10.1126/science.7886456 · 被引用次数：568 · 研究领域：Helicobacter pylori-related gastroenterology studies、Galectins and Cancer Biology、Eosinophilic Esophagitis

The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.