Incidence of Primary Hyperparathyroidism in Rochester, Minnesota, 1993–2001: An Update on the Changing Epidemiology of the Disease

作者：Robert A. Wermers, Sundeep Khosla, Elizabeth J. Atkinson, Sara J. Achenbach, Ann L. Oberg, Clive S. Grant, L. Joseph Melton · 发表于：Journal of Bone and Mineral Research · 年份：2006 · DOI：10.1359/jbmr.050910 · 被引用次数：447 · 研究领域：Parathyroid Disorders and Treatments、Vitamin D Research Studies、Thyroid and Parathyroid Surgery

UNLABELLED: We updated the incidence of primary hyperparathyroidism in Rochester, Minnesota. The lower rates previously noted persisted, whereas parathyroidectomies at our institution remained high. These data suggest an etiologic factor may be responsible for the peak incidence in the 1970s. INTRODUCTION: Automated serum calcium measurements were associated with a dramatic rise in primary hyperparathyroidism in the early 1970s, but a progressive decline in the incidence thereafter was unexpected and suggested a fundamental change in the epidemiology of the disease. Our objective was to evaluate trends in the incidence of primary hyperparathyroidism since 1992. MATERIALS AND METHODS: In this population-based descriptive study, Rochester, MN, residents who met defined diagnostic criteria for primary hyperparathyroidism from January 1993 through December 2001 were identified through the medical record linkage system of the Rochester Epidemiology Project and the Mayo Clinic Laboratory Information System. Changes in incidence were evaluated by Poisson regression. RESULTS: Altogether, 136 Rochester residents (94 women and 42 men) were newly identified with primary hyperparathyroidism in 1993-2001. Their mean age was 56 years, and 93% had definite disease. The overall age- and sex-adjusted (to 2000 U.S. whites) rate during this period was 21.6 per 100,000 person-years, which was less than the annual rate of 29.1 per 100,000 observed in 1983-1992 and 82.5 per 100,000 in July 1974-19...