Oral Contraceptive and Postmenopausal Estrogen Effects on Lipoprotein Triglyceride and Cholesterol in an Adult Female Population: Relationships to Estrogen and Progestin Potency*

作者：Robert H. Knopp, Carolyn E. Walden, Patricia W. Wahl, Joanne Hoover, G. Russell Warnick, John J. Albers, James T. Ogilvie, William R. Hazzard · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：1981 · DOI：10.1210/jcem-53-6-1123 · 被引用次数：102 · 研究领域：Reproductive Health and Contraception、Hormonal and reproductive studies、Menopause: Health Impacts and Treatments

A study of the prevalence of hyperlipidemia has been conducted among female telephone company employees using oral contraceptive steroids or estrogenic hormones. This paper relates hormone formulation and estogen⁄progestin potency to triglyceride and cholesterol concentrations in total plasma and lipoprotein fractions and relative lipid composition. Changes in these lipid parameters are of interest because they may predict atherosclerosis risk. Results in 148 hormone users are compared with those in 306 nonhormone users. All data are adjusted for the effects of age, relative body weight, cigarette smoking, and alcohol intake. Triglyceride concentrations in whole plasma, very low density lipoprotein (VLDL), and high density lipoprotein (HDL) are elevated 1.5- to 2.5-fold with increasing estrogen potency. Low density lipoprotein (LDL) triglyceride concentration is elevated to a similar degree among oral contraceptive users regardless of estrogen potency, but there is no significant effect of postmenopausal estrogen use on LDL triglyceride concentrations. The LDL cholesterol concentration shows an increasing trend with increasing estrogen potency in a random sample of oral contraceptive- treated women, but is slightly lower than control in postmenopausal women treated with estrogen alone. The HDL cholesterol concentration in plasma is highest with hormones having the greatest estrogen potency and lowest with those having the greatest progestin potency. The VLDL cholesterol to tr...