Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

作者：Elena H. Martínez‐Lapiscina, Pedro Clavero, Estefanía Toledo, Bao-Quyn Julian, Ana Sánchez‐Tainta, Dolores Corella, Rosa M. Lamuela‐Raventós, J. Alfredo Martínéz, Miguel Ángel Martínez‐González · 发表于：The journal of nutrition health & aging · 年份：2013 · DOI：10.1007/s12603-013-0027-6 · 被引用次数：267 · 研究领域：Nutritional Studies and Diet、Nuts composition and effects、Diet and metabolism studies

OBJECTIVE: To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet). DESIGN: Randomized trial after 6.5 years of nutritional intervention. SETTING: Eight primary care centers affiliated to the University of Navarra. PARTICIPANTS: A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation). INTERVENTIONS: Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter. MEASUREMENTS: Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention. RESULTS: Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated ...