Maturational Changes in Cerebral Function in Infants Determined by 18 FDG Positron Emission Tomography

作者：Harry T. Chugani, Michael E. Phelps · 发表于：Science · 年份：1986 · DOI：10.1126/science.3945811 · 被引用次数：673 · 研究领域：Medical Imaging Techniques and Applications、Neonatal and fetal brain pathology、Hyperglycemia and glycemic control in critically ill and hospitalized patients

2-Deoxy-2[18F]fluoro-D-glucose positron emission tomography performed in human infants during development revealed progressive changes in local cerebral glucose utilization. In infants 5 weeks of age and younger, glucose utilization was highest in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months. These functional changes measured with positron emission tomography are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.