MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

作者：Eva van Rooij, Eric N. Olson · 发表于：Journal of Clinical Investigation · 年份：2007 · DOI：10.1172/jci33099 · 被引用次数：555 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Extracellular vesicles in disease

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.