METABOLISM OF CATECHOL ESTROGEN BY HUMAN ERYTHROCYTES

作者：G. William Bates, Clare D. Edman, J. C. Porter, Paul C. MacDonald · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：1977 · DOI：10.1210/jcem-45-5-1120 · 被引用次数：30 · 研究领域：Hormonal and reproductive studies

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC's was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.